The today St. Louis Nursery and Primary Owo was founded by Fr. Akinluyi, the Parish priest of St. Francis Catholic church Owo. The school was then called St. David’s Nursery and Primary school, Owo. It started at St. Francis Catholic church Hall in Owaluwa in 1992 with Father Cajetan Famakinwa who was then a seminarian as the headmaster.

In 1993, the sisters of St. Louis were invited to run the school and that was when it was moved to St. Louis Hospital Compound with Sr. Winifred Ojo as the first headmistress. By September that same year, the number of pupils had grown to about one hundred and fifty.